Anthony P. Goldstone, M.A., M.D., Ph.D.

Senior Clinician Scientist and Consultant Endocrinologist, Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College London, UK

Education:
M.D., Cambridge and Oxford Universities, United Kingdom; Ph.D. Imperial College, London

Research Interests:
Dr. Goldstone has researched and published widely on neuroendocrine and metabolic abnormalities in Prader-Willi syndrome and early-onset morbid obesity, particularly investigating the causes of hyperphagia and obesity, through clinical, post-mortem, animal model, genetic, interventional, fat and brain imaging studies. This includes work as a research fellow at the Netherlands Institute for Brain Research in Amsterdam and the Division of Pediatric Genetics at the University of Florida.

A major theme of his current work is using functional magnetic resonance imaging to investigate appetite and eating behavior in humans. He also supports a multi-disciplinary paediatric clinic for patients with PWS.

He was a member of the Scientific Committee for the 2nd PWS Expert meeting, Toulouse, France in 2006 and the 6th PWS International Conference, Cluj, Romania in 2007, and has been a Vice-President of the UK PWS Association since 2007. He is the Scientific Co-Chair of this 1st International Hyperphagia Conference.

Selected Publications:
Visceral adipose tissue and metabolic complications of obesity are reduced in Prader-Willi syndrome female adults: evidence for novel influences on body fat distribution. A.P.Goldstone, E.L.Thomas, A.E.Brynes, J.D.Bell, G.Frost, J.V.Hajnal, N.Saeed, J.K.Howard, A.Holland & S.R.Bloom Journal of Clinical Endocrinology and Metabolism 86: 4330-4338, 2001

Hypothalamic NPY and AGRP are increased in human illness but not in Prader-Willi syndrome and other obese subjects A.P.Goldstone, U.A.Unmehopa, S.R.Bloom & D.F.Swaab Journal of Clinical Endocrinology and Metabolism 87:927-937, 2002

Resting metabolic rate, plasma leptin concentrations, leptin receptor expression, and adipose tissue measured by whole-body magnetic resonance imaging in women with Prader-Willi syndrome. A.P.Goldstone, A.E.Brynes, E.L.Thomas, J.D.Bell, G.Frost, A.Holland, M.A.Ghatei & S.R.Bloom American Journal of Clinical Nutrition 75:468-475, 2002

Hypothalamic growth hormone-releasing hormone (GHRH) cell number is increased in human illness, but is not reduced in Prader-Willi syndrome or obesity. A.P.Goldstone, U.A.Unmehopa & D.F.Swaab Clinical Endocrinology 58:743-755, 2003 (erratum 59:266, 2003)

Somatostatin infusion lowers plasma ghrelin without reducing appetite in adults with Prader-Willi syndrome
T.M-M.Tan, M.Vanderpump, B.Khoo, M.Patterson, M.A.Ghatei & A.P.Goldstone Journal of Clinical Endocrinology and Metabolism 89: 4162-4165, 2004

Prader-Willi syndrome: advances in genetics, pathophysiology and treatment A.P.Goldstone Trends in Endocrinology and Metabolism 15:12-20, 2004

Fasting and post-prandial hyperghrelinemia in Prader-Willi syndrome is partially explained by hypoinsulinemia, and is not due to peptide YY3-36 deficiency or seen in hypothalamic obesity due to craniopharyngioma A.P.Goldstone, M. Patterson, N.Kalingag, M.A.Ghatei, A.E.Brynes, S.R.Bloom, A.B.Grossman & M.Korbonits Journal of Clinical Endocrinology and Metabolism 90:2681-2690, 2005

Enhanced activation of reward-mediating prefrontal regions in response to food stimuli in Prader-Willi syndrome J.L.Miller, G.A.James, A.P.Goldstone, J.Couch, G.He, D.J.Driscoll & Y.Liu Journal of Neurology, Neurosurgery, and Psychiatry 78:615-9, 2007

Genetic obesity syndromes A.P.Goldstone & P.L.Beales Frontiers of Hormone Research 36:37-60, 2008

Recommendations for the diagnosis and management of Prader-Willi syndrome A.P. Goldstone, A.J. Holland, B.P. Hauffa, A.C. Hokken-Koelega & M. Tauber Journal of Clinical Endocrinology & Metabolism 9:4183-4197, 2008